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VPS35, the core component of the retromer complex, and Parkinson's disease

1 Dec 2021

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease that is common in middle-aged and elderly people, and its onset is related to multiple factors, such as heredity, environment, and age. The vesicle protein sorting 35 (VPS35) gene was found to be a late-onset autosomal dominant familial PD (PARK17) causative gene. The protein encoded by this gene is located in the endosome and aggregates with other membrane...

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PMID: 37786555
DOI: 10.1002/ibra.12004

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