Article

NSUN2-dependent 5-methylcytosine Modification Regulates Influenza A virus Gene Expression and Genomic Packaging

2025-11-26

Abstract excerpt

Emerging evidence indicates that methyltransferase NSUN2 catalyzes 5-methylcytosine (m 5 C) modifications on various viral RNAs and plays important roles in viral biology. However, the regulatory roles of NSUN2 in influenza A virus (IAV) replication have not been elucidated. Here, we revealed that NSUN2 negatively regulated the viral RNA transcription and protein production by knocking out and over-expressing NS...

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Literature Corpus work: c0f21eb5-c1e2-58b6-b955-0c615e52704d
DOI: 10.1101/2025.11.26.690652

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