Article

Mapping the complete influenza A virus infection cycle through single vRNP imaging

2025-01-20

Abstract excerpt

Cell-to-cell heterogeneity is a common feature of viral infection that can generate enormous complexity, complicating understanding of infection progression and interpretation of differences between viral variants. To overcome these challenges, we developed a technology to visualize the infection cycle of human influenza A virus (IAV) from start-to-finish in individual living cells with unprecedented spatial and t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4d1774d-c427-590b-8ef1-5b40561d18cc
DOI: 10.1101/2025.01.20.633851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the complete influenza A virus infection cycle through single vRNP imagingDOI 10.1101/2025.01.20.633851Read

Analysis of IAV Replication and Co-infection Dynamics by a Versatile RNA Viral Genome Labeling MethodSemantic proximity Read

Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replicationSemantic proximity Read

Detailed single-cell mapping of the transcriptional response to a virus infection driven by copy-back viral genomesSemantic proximity Read

Virus Infection Variability by Single-Cell ProfilingSemantic proximity Read

Single-cell transcriptional dynamics of flavivirus infectionSemantic proximity Read

Selective flexible packaging pathways of the segmented genome of influenza A virusSemantic proximity Read

The use of single-cell RNA-seq to study heterogeneity at varying levels of virus–host interactionsSemantic proximity Read

Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomicsSemantic proximity Read

Influenza A virus defective viral genomes are inefficiently packaged into virions relative to wild-type genomic RNAsSemantic proximity Read

Plaque2.0-A High-Throughput Analysis Framework to Score Virus-Cell Transmission and Clonal Cell Expansion.Semantic proximity Read

Single cell heterogeneity in influenza A virus gene expression shapes the innate antiviral response to infectionSemantic proximity Read

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populationsSemantic proximity Read