Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference.

doi:10.1038/s41467-026-74526-7

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Article

Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference.

Nature communications - 16 Jun 2026

Alnaji Fadi G, Farjo Mireille, Goh Shu Ling, Zheng Hao Aw Daryl, Lorenzini Paolo Alberto, Liu Tongyu, Lin-Zhen Chan Rebekah, Lee Cornelius, Vignuzzi Marco, Brooke Christopher B

Abstract excerpt

Influenza A virus populations contain substantial genetic diversity. A major contributor to this diversity is the ubiquitous production of deletion-containing viral genomes (DelVGs) - viral RNAs with large internal deletions. DelVGs directly compete with wild-type (WT) genomes and have been implicated in modulating disease severity. However, the specific functional and genetic interactions between DelVGs and WT...

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PMID: 42303613
DOI: 10.1038/s41467-026-74526-7
PMCID: PMC13522585

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