Article

Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy

2020-02-04

Abstract excerpt

The genetic basis of variation in the rate of disease progression of primary tauopathies has not been determined. In two independent progressive supranuclear palsy cohorts, we show that common variation at the LRRK2 locus determines survival from motor symptom onset to death, possibly through regulation of gene expression. This links together genetic risk in alpha-synuclein and tau disorders, and suggests that mo...

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Literature Corpus work: 6f64bb29-e6e3-5755-8d34-f7e20e2ece9f
DOI: 10.1101/2020.02.04.932335

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