Article
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Nature genetics - 19 Jun 2011
Höglinger Günter U, Melhem Nadine M, Dickson Dennis W, Sleiman Patrick M A, Wang Li-San, Klei Lambertus, Rademakers Rosa, de Silva Rohan, Litvan Irene, Riley David E, van Swieten John C, Heutink Peter, Wszolek Zbigniew K, Uitti Ryan J, Vandrovcova Jana, Hurtig Howard I, Gross Rachel G, Maetzler Walter, Goldwurm Stefano, Tolosa Eduardo, Borroni Barbara, Pastor Pau, Cantwell Laura B, Han Mi Ryung, Dillman Allissa, van der Brug Marcel P, Gibbs J Raphael, Cookson Mark R, Hernandez Dena G, Singleton Andrew B, Farrer Matthew J, Yu Chang-En, Golbe Lawrence I, Revesz Tamas, Hardy John, Lees Andrew J, Devlin Bernie, Hakonarson Hakon, Müller Ulrich, Schellenberg Gerard D
Abstract excerpt
Progressive supranuclear palsy (PSP) is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide...
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