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S tudy of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration

6 Oct 2016

Abstract excerpt

BACKGROUND: Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common genetic cause of Parkinson's disease (PD). Unexpectedly, tau pathology has been reported in a subset of LRRK2 mutation carriers. METHODS: To estimate the frequency of pathogenic LRRK2 mutations and to evaluate the association of common LRRK2 variants with risk of primary tauopathies, we studied 1039 progressive supranuclear...

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PMID: 27709685
DOI: 10.1002/mds.26815

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