Article
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study.
The Lancet. Neurology - 1 Feb 2021
Jabbari Edwin, Koga Shunsuke, Valentino Rebecca R, Reynolds Regina H, Ferrari Raffaele, Tan Manuela M X, Rowe James B, Dalgard Clifton L, Scholz Sonja W, Dickson Dennis W, Warner Thomas T, Revesz Tamas, Höglinger Günter U, Ross Owen A, Ryten Mina, Hardy John, Shoai Maryam, Morris Huw R
Abstract excerpt
BACKGROUND: The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP). METHODS: In stage one of this two stage genome-wide association study (GWAS), we included individuals with PSP, diagnosed according to pathological and clinical criteria, from two separate cohorts: the 2011 PSP...
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