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Sperm motility in mice with oligo-astheno-teratozoospermia restored by <i>in vivo</i> injection and electroporation of naked mRNA

2023-12-14

Abstract excerpt

Oligo-astheno-teratozoospermia (OAT), a recurent cause of male infertility, is the most frequent disorder of spermatogenesis with a probable genetic cause. Patients and mice bearing mutations in the ARMC2 gene have a decreased sperm concentration, and individual sperm show multiple morphological defects and a lack of motility – a canonical OAT phenotype. Intracytoplasmic sperm injection (ICSI) is required to trea...

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Literature Corpus work
6f3bd16b-bc28-5ce1-8c16-04c26d723d38
DOI
10.1101/2023.12.12.571239
Open publication

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Sperm motility in mice with oligo-astheno-teratozoospermia restored by <i>in vivo</i> injection and electroporation of naked mRNADOI 10.1101/2023.12.12.571239
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