<scp>AAV</scp>‐mediated gene therapy restores natural fertility and improves physical function in the <i>Lhcgr</i>‐deficient mouse model of <scp>Leydig</scp> cell failure

Abstract excerpt

Abstract Leydig cell failure (LCF) caused by gene mutations leads to testosterone deficiency, infertility and reduced physical function. Adeno‐associated virus serotype 8 (AAV8)‐mediated gene therapy shows potential in treating LCF in the Lhcgr‐deficient ( Lhcgr −/− ) mouse model. However, the gene‐treated mice still cannot naturally sire offspring, indicating the modestly restored testosterone and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Share to Reproductive Biology and Fertility