Back to search

Article

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

2025-05-23

Abstract excerpt

Uniform testicular maturation arrest is a severe form of male infertility characterized by the presence of germ cells that do not complete spermatogenic development. It is usually caused by meiotic arrest with genetic variants and difficult to treat via drugs or surgery. mRNA-lipid nanoparticle (LNP) delivery is a promising therapeutic option for maturation arrest with monogenic variants via protein replacement th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6eb93253-22c3-5e13-8d93-1c2fb01d44f8
DOI
10.1101/2025.05.21.654986
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic DisordersDOI 10.1101/2025.05.21.654986
Testis electroporation coupled with autophagy inhibitor to treat non-obstructive azoospermiaSemantic proximity
Engineering temporal alignment of mRNA delivery enables functional rescue across genetic infertility modelsSemantic proximity
Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive TargetsSemantic proximity
Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice.Semantic proximity
Transgenerational Inheritance Effects of Copper Oxide Nanoparticles (CuONPs) Induced Asthenospermia and Infertility via Gamete H3K9me3 Insufficiency Pathway in MiceSemantic proximity
Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapiesSemantic proximity
The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesisSemantic proximity
KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.Semantic proximity
YTHDF2 is essential for spermatogenesis and fertility through mediating a wave of transcript transition during spermatogonial differentiationSemantic proximity
Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesisSemantic proximity
Leydig cell metabolic disorder act as a new mechanism affecting for focal spermatogenesis in Klinefelter syndrome patients: a real world cross-sectional study base on the ageSemantic proximity
The Evolutionary Route of in vitro Human Spermatogenesis: What is the Next Destination?Semantic proximity
Select a neighboring publication to make it the new centre.