Article

Engineering temporal alignment of mRNA delivery enables functional rescue across genetic infertility models

2025-11-14

Abstract excerpt

Genetic male infertility arises from diverse mutations that disrupt spermatogenesis, yet therapeutic strategies capable of restoring germ-cell function remain limited. Messenger RNA (mRNA) therapeutics offer a programmable and non-integrating approach, but their functional compatibility in structured and immune-privileged tissues remains unclear. Here we identify a temporal mismatch between mRNA delivery kinetics...

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Literature Corpus work: 0e1e873c-f4a1-5920-9162-d5699e46f0af
DOI: 10.1101/2025.11.13.688269

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