Article

Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states

2024-12-15

Abstract excerpt

Muscle-type nicotinic acetylcholine receptor (AChR) is the key signalling molecule in neuromuscular junctions. Here we present the structures of full-length human adult receptors in complex with Fab35 in α-bungarotoxin (αBuTx)-bound resting states, and in acetylcholine (ACh)-bound desensitised states. In addition to identifying the conformational changes during recovery from desensitisation, we also used electroph...

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Identifiers and source

Literature Corpus work: 60445259-ddbc-5bf2-9856-2a9c4437c70b
DOI: 10.1101/2024.12.13.624530

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