Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Erabutoxin mutants demonstrate interface selectivity at human fetal and adult muscle-type nicotinic acetylcholine receptors.

Biochemical pharmacology - 1 Nov 2025

Chan Christabel Y L, Tae Han-Shen, Koh Cho Yeow, Adams David J, Kini R Manjunatha

Abstract excerpt

α-Neurotoxins, a prominent class of snake toxins belonging to the three-finger toxin (3FTx) superfamily, function as orthosteric antagonists of postsynaptic nicotinic acetylcholine receptors (nAChRs). Due to their high selectivity, α-neurotoxins have been widely used to characterize these physiologically important receptors. In this study, we investigated the concentration-response relationships of wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Nicotinic Antagonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oocytes

Share to Receptors, Nicotinic

Share to Xenopus laevis

Source

Identifiers

PMID: 40716651
DOI: 10.1016/j.bcp.2025.117189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Erabutoxin mutants demonstrate interface selectivity at human fetal and adult muscle-type nicotinic acetylcholine receptors.PMID 40716651Read ↗

Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism.Semantic proximity Read ↗

Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanism.Semantic proximity Read ↗

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.Semantic proximity Read ↗

Structural basis of agonist selectivity for different nAChR subtypes: insights from crystal structures, mutation experiments and molecular simulations.Semantic proximity Read ↗

Evolutionary diversification of Mesobuthus α-scorpion toxins affecting sodium channels.Semantic proximity Read ↗

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.Semantic proximity Read ↗

Efficient binding of 4/7 α-conotoxins to nicotinic α4β2 receptors is prevented by Arg185 and Pro195 in the α4 subunit.Semantic proximity Read ↗

Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.Semantic proximity Read ↗

Single amino acid substitutions modulate the function of α9α10 nicotinic acetylcholine receptor.Semantic proximity Read ↗

Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.Semantic proximity Read ↗

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function.Semantic proximity Read ↗

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.