Multi-omics integration identifies associations between large high-density lipoprotein and lung function, asthma, and COPD: evidence from genetic and population-based analyses.

Abstract excerpt

BACKGROUND: Metabolomic signatures of lung function and chronic inflammatory respiratory diseases have been associated with potential early disease processes. We aimed to investigate the genetic correlations and causal relationships of plasma metabolites with lung function and chronic respiratory inflammatory diseases. METHODS: Leveraging large-scale genome-wide association study (GWAS) summary-level data and...

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