Article
Roles of HMGA proteins in cancer.
Nature reviews. Cancer - 1 Dec 2007
Fusco Alfredo, Fedele Monica
Abstract excerpt
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumours. Conversely,...
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