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Article

Cellular carcinogenesis in preleukemic conditions:drivers and defenses.

Fukushima journal of medical science - 27 Jan 2024

Ueda Koki, Ikeda Kazuhiko

Abstract excerpt

Acute myeloid leukemia (AML) arises from preleukemic conditions. We have investigated the pathogenesis of typical preleukemia, myeloproliferative neoplasms, and clonal hematopoiesis. Hematopoietic stem cells in both preleukemic conditions harbor recurrent driver mutations; additional mutation provokes further malignant transformation, leading to AML onset. Although genetic alterations are defined as the main...

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Share to Hematopoietic Stem Cells
Share to Cell Transformation, Neoplastic
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37952978
DOI: 10.5387/fms.2023-17
PMCID: PMC10867434

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