Article

Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells

2017-08-11

Abstract excerpt

CTCF is an evolutionarily conserved and ubiquitously expressed architectural protein regulating a plethora of cellular functions via different molecular mechanisms. CTCF can undergo a number of post-translational modifications which change its properties and functions. One such modifications linked to cancer is poly(ADP-ribosyl)ation (PARylation). The highly PARylated CTCF form has an apparent molecular mass of 18...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f0a3e10-8c40-565d-b64e-e42838de48cb
DOI: 10.1101/175448

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cellsDOI 10.1101/175448Read

Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation.Semantic proximity Read

Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulationSemantic proximity Read

The CTCF Paralog BORIS Contributes to the Ovarian Cancer Transcriptional Program by Relaxing CTCF-mediated 3D Genome OrganizationSemantic proximity Read

CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer.Semantic proximity Read

The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancerSemantic proximity Read

O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancerSemantic proximity Read

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancersSemantic proximity Read

Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation.Semantic proximity Read

O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancerSemantic proximity Read

Modifying chromatin and concepts of cancer.Semantic proximity Read

Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer TherapySemantic proximity Read

Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.Semantic proximity Read