Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer

3 Jul 2024

Abstract excerpt

Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-throughput combinatorial drug screening and genomic sequencing, we find that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Glycosylation and Glycoproteins Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38961064
DOI: 10.1038/s41467-024-49875-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancerPMID 38961064Read ↗

O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancerSemantic proximity Read ↗

A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitorsSemantic proximity Read ↗

Charting the Multi-level Molecular Response to Palbociclib in ER-Positive Breast CancerSemantic proximity Read ↗

Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinomaSemantic proximity Read ↗

Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategiesSemantic proximity Read ↗

Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinasesSemantic proximity Read ↗

Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapySemantic proximity Read ↗

O‐GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistanceSemantic proximity Read ↗

LncRNA EILA promotes CDK4/6 inhibitor resistance in breast cancer by stabilizing cyclin E1 proteinSemantic proximity Read ↗

PI3K signaling-mediated BAP1 O-GlcNAcylation promotes breast cancer malignancy by dual regulation of OGT stability and FOXM1 condensationSemantic proximity Read ↗

CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant TP53 Transcription.Semantic proximity Read ↗

Role of UFMylation in tumorigenesis and cancer immunotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.