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O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer

2023-10-03

Abstract excerpt

<title>Abstract</title> <p>Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-throughput combinatorial drug screening and genomic sequencing, we found tha...

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Literature Corpus work
009db333-3822-5060-b921-975ada1f4fa1
DOI
10.21203/rs.3.rs-3377962/v1
Open publication

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O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancerDOI 10.21203/rs.3.rs-3377962/v1
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