Article
Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, is associated with breast cancer phenotype and cell proliferation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2009
Docquier France, Kita Georgia-Xanthi, Farrar Dawn, Jat Parmjit, O'Hare Michael, Chernukhin Igor, Gretton Svetlana, Mandal Adhip, Alldridge Louise, Klenova Elena
Abstract excerpt
PURPOSE: There is compelling evidence of a relationship between poly(ADP-ribosyl)ation and tumorigenesis; however, much less is known about the role of specific targets of poly(ADP-ribosyl)ation in tumor development. Two forms of the multifunctional transcription factor, CTCF, were previously identified: a 130-kDa protein (CTCF-130), characteristic for cell lines, and a 180-kDa protein (CTCF-180), modified by...
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