Article

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

2020-02-21

Abstract excerpt

Reverse genetics has been an indispensable tool revolutionising our insights into viral pathogenesis and vaccine development. Large RNA virus genomes, such as from Coronaviruses, are cumbersome to clone and to manipulate in E. coli hosts due to size and occasional instability 1-3 . Therefore, an alternative rapid and robust reverse genetics platform for RNA viruses would benefit the research community. Here we s...

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Literature Corpus work: 6f065a75-62d5-51b8-81d0-93ab3ccdbdf6
DOI: 10.1101/2020.02.21.959817

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