Article

De novo transformer modeling improves recovery of genetic cell types from sparse single-cell RNA sequencing

2026-08-07

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) simultaneously provides gene-expression profiles and genetic variants from individual cells, creating an opportunity to relate cellular phenotypes to their somatic evolutionary histories. However, delineation of genetic type (GTs) from scRNA-seq remains difficult because most variant positions are unobserved in individual cells and the observed base calls contain substantial...

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Literature Corpus work: 6eeab2d0-43af-5b3c-8381-84e795466718
DOI: 10.64898/2026.08.03.742620

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