Article

Engineering Human ARMMs as Therapeutic Non-Viral Vehicles for <i>in vivo</i> Delivery of Genome Editing Payloads

2024-09-26

Abstract excerpt

The ability to edit the human genome to treat previously incurable diseases or to modify previously undruggable targets has the potential to transform the lives of patients. However, delivery of genome editing machineries in vivo , and in a transient manner, continues to be a major challenge. We engineered human cell-derived ARRDC1-mediated microvesicles (ARMMs) as non-viral vehicles that mediate intracellular de...

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Literature Corpus work: 574120b2-9ce8-569d-be69-bc33ad3ed94f
DOI: 10.1101/2024.09.24.614725

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