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CRISPR delivery with extracellular vesicles: Promises and challenges

1 Sept 2023

Abstract excerpt

The CRISPR gene editing tool holds great potential for curing genetic disorders. However, the safe, efficient, and specific delivery of the CRISPR/Cas9 components into cells and tissues remains a challenge. While many currently available delivery methods achieve high levels of gene editing effects in vivo, they often result in genotoxicity and immunogenicity. Extracellular vesicles (EVs), which are cell-derived...

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PMID: 38938376
DOI: 10.1002/jex2.111

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