Packaging and Uncoating of CRISPR/Cas Ribonucleoproteins for Efficient Gene Editing with Viral and Non-viral Extracellular Nanoparticles

Abstract excerpt

Rapid progress in gene editing based on clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) has revolutionized the study of gene and genome function and genetic disease correction. While numerous genetically modified cellular and animal models have been created to understand biological processes, the clinical application of CRISPR/Cas tools has been impeded by off-targe...

Topics

Open a Topic to create a Post that cites this publication.

• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Extracellular Vesicles
• Gene Editing
• Gene Transfer Techniques
• Mutation
• RNA
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

d15147ff-70ec-5913-8523-1708490054a1

DOI

10.20944/preprints202212.0529.v1