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Article

VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9

11 Jul 2018

Abstract excerpt

The method of delivery of CRISPR-Cas9 into target cells is a strong determinant of efficacy and specificity in genome editing. Even though high efficiency of Cas9 delivery is necessary for optimal editing, its long-term and high levels of expression correlate with increased off-target activity. We developed vesicles (VEsiCas) carrying CRISPR-SpCas9 ribonucleoprotein complexes (RNPs) that are efficiently delivered...

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PMID: 30195783
DOI: 10.1016/j.omtn.2018.05.010

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