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Article

Overview on applications of antisense-mediated exon skipping.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

van Roon-Mom Willeke M C, Aartsma-Rus Annemieke

Abstract excerpt

Antisense-mediated exon skipping has multiple therapeutic applications. This chapter gives an overview of how this tool has been employed to restore normal splicing for cryptic splicing mutations, to switch between alternative splicing isoforms, to induce exon inclusion, to correct the reading frame to allow the production of internally deleted proteins, or to induce reading frame disruptions to achieve partial...

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PMID: 22454056
DOI: 10.1007/978-1-61779-767-5_6

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