Article

SATB2 induction of a neural crest mesenchyme-like program drives invasion and drug resistance in melanoma

2020-11-02

Abstract excerpt

Recent genomic and scRNA-seq analyses of melanoma identified common transcriptional states correlating with invasion or drug resistance, but failed to find recurrent drivers of metastasis. To test whether transcriptional adaptation can drive melanoma progression, we made use of a zebrafish mitfa:BRAFV600E;tp53-/- model, in which malignant progression is characterized by minimal genetic evolution. We undertook an...

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Literature Corpus work: 6ebc78c0-469f-5fde-8e23-9a7f612804d6
DOI: 10.1101/2020.11.01.364406

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