Article

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

2019-08-01

Abstract excerpt

<h4>Summary</h4> Parkinson’s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons within the substantia nigra pars compacta and the presence of protein aggregates in surviving neurons. LRRK2 G2019S mutation is one of the major determinants of familial PD cases and leads to late-onset PD with pleomorphic pathology, including alpha-synuclein accumulation and deposition of protein in...

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Literature Corpus work: 6eaeb052-230d-556f-9936-3fcb6875289e
DOI: 10.1101/721266

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