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Article

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Sept 2010

Lin Chin-Hsien, Tsai Pei-I, Wu Ruey-Meei, Chien Cheng-Ting

Abstract excerpt

Intraneuronal tau aggregations are distinctive pathological features of Parkinson's disease (PD) with autosomal-dominant mutations in leucine-rich repeat kinase 2 (LRRK2). The most prevalent LRRK2 mutation, G2019S (glycine to serine substitution at amino acid 2019), causes neurite shrinkage through unclear pathogenetic mechanisms. We found that expression of G2019S mutant in Drosophila dendritic arborization...

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Identifiers

PMID: 20881132
DOI: 10.1523/JNEUROSCI.1737-10.2010
PMCID: PMC6633523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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