Article
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Molecular neurodegeneration - 13 Jan 2016
Belluzzi Elisa, Gonnelli Adriano, Cirnaru Maria-Daniela, Marte Antonella, Plotegher Nicoletta, Russo Isabella, Civiero Laura, Cogo Susanna, Carrion Maria Perèz, Franchin Cinzia, Arrigoni Giorgio, Beltramini Mariano, Bubacco Luigi, Onofri Franco, Piccoli Giovanni, Greggio Elisa
Abstract excerpt
BACKGROUND: Lrrk2, a gene linked to Parkinson's disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the presynaptic site, LRRK2 associates with synaptic vesicles through interaction with a panel of presynaptic proteins. RESULTS: Here, we show that LRRK2 kinase activity influences the dynamics of synaptic vesicle fusion. We...
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