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Article

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.

Brain : a journal of neurology - 22 Jun 2021

Pischedda Francesca, Cirnaru Maria Daniela, Ponzoni Luisa, Sandre Michele, Biosa Alice, Carrion Maria Perez, Marin Oriano, Morari Michele, Pan Lifeng, Greggio Elisa, Bandopadhyay Rina, Sala Mariaelvina, Piccoli Giovanni

Abstract excerpt

Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons within the substantia nigra pars compacta and the presence of protein aggregates in surviving neurons. The LRRK2 G2019S mutation is one of the major determinants of familial Parkinson's disease cases and leads to late-onset Parkinson's disease with pleomorphic pathology, including α-synuclein accumulation and deposition...

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Identifiers

PMID: 33876242
DOI: 10.1093/brain/awab073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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