Article
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
Genes & development - 1 Oct 2006
Vanselow Katja, Vanselow Jens T, Westermark Pål O, Reischl Silke, Maier Bert, Korte Thomas, Herrmann Andreas, Herzel Hanspeter, Schlosser Andreas, Kramer Achim
Abstract excerpt
PERIOD (PER) proteins are central components within the mammalian circadian oscillator, and are believed to form a negative feedback complex that inhibits their own transcription at a particular circadian phase. Phosphorylation of PER proteins regulates their stability as well as their subcellular localization. In a systematic screen, we have identified 21 phosphorylated residues of mPER2 including Ser 659, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.