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Article

Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits.

Genome biology - 22 Apr 2021

Rizzardi Lindsay F, Hickey Peter F, Idrizi Adrian, Tryggvadóttir Rakel, Callahan Colin M, Stephens Kimberly E, Taverna Sean D, Zhang Hao, Ramazanoglu Sinan, Hansen Kasper D, Feinberg Andrew P

Abstract excerpt

BACKGROUND: DNA methylation dynamics in the brain are associated with normal development and neuropsychiatric disease and differ across functionally distinct brain regions. Previous studies of genome-wide methylation differences among human brain regions focus on limited numbers of individuals and one to two brain regions. RESULTS: Using GTEx samples, we generate a resource of DNA methylation in purified neuronal...

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Identifiers

PMID: 33888138
DOI: 10.1186/s13059-021-02335-w
PMCID: PMC8061076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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