Investigating the role of TRPA1 and TRPV1 ion channels in the cough reflex

Abstract excerpt

Cough is under the control of sensory afferents which innervate the airways via the vagus nerve. Cough is an important protective reflex that clears the airway, but can become exacerbated and deleterious when associated with airways diseases, in which there is enhanced release of inflammatory mediators and a decrease in lung pH. These mediators sensitise airway afferents and could be driving enhanced cough associa...

Topics

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• Biochemical Analysis and Sensing Techniques
• Gene Knockout Techniques
• Membrane Potentials
• Mutation
• Neuroscience of respiration and sleep
• Protein Stability
• Respiratory and Cough-Related Research
• TRPV Cation Channels

Identifiers and source

Literature Corpus work

f379774a-c007-53d0-823e-8f007d418b9e

DOI

10.25560/14571