Article

The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice

2024-11-19

Abstract excerpt

<h4>Objective</h4> Osteoarthritis (OA) has a multifactorial pathogenesis, pain being the main symptom driving clinical decision making. Dysregulation of multiple mediators occurs in OA, the roles of many remaining to be identified. In dogs and humans with OA, synovial fluid lipidome dysregulation occurs, some findings being replicated in the plasma lipidome in a mouse OA model. One upregulated lipid is the sphing...

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Literature Corpus work: 14a45592-9888-5109-81c6-d2329cf340cc
DOI: 10.1101/2024.11.19.621807

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