Article

N-terminal mutants of human apolipoprotein A-I: structural perturbations associated to protein misfolding

2019-01-14

Abstract excerpt

Since the early description of different human apolipoprotein A-I variants associated to amyloidosis, the reason that determines its deposition inducing organ failure has been under research. To shed light into the events associated to protein aggregation, we studied the effect of the structural perturbations induced by the replacement of a Leucine in position 60 by an Arginine as it occurs in the natural amyloido...

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Literature Corpus work: 6e90c1ba-b18b-5bc8-8cff-bf7fa87692f3
DOI: 10.1101/520171

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