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Article

DE-loop mutations affect beta2 microglobulin stability, oligomerization, and the low-pH unfolded form.

Protein science : a publication of the Protein Society - 1 Jul 2010

Santambrogio Carlo, Ricagno Stefano, Colombo Matteo, Barbiroli Alberto, Bonomi Francesco, Bellotti Vittorio, Bolognesi Martino, Grandori Rita

Abstract excerpt

Beta2 microglobulin (beta2m) is the light chain of class-I major histocompatibility complex (MHC-I). Its accumulation in the blood of patients affected by kidney failure leads to amyloid deposition around skeletal joints and bones, a severe condition known as Dialysis Related Amyloidosis (DRA). I...

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Identifiers

PMID: 20506535
DOI: 10.1002/pro.419
PMCID: PMC2974830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20506535-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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