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Article

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: assessment by 15N NMR relaxation.

Magnetic resonance in chemistry : MRC - 1 Dec 2013

Gümral Devrim, Fogolari Federico, Corazza Alessandra, Viglino Paolo, Giorgetti Sofia, Stoppini Monica, Bellotti Vittorio, Esposito Gennaro

Abstract excerpt

The amyloid pathology associated with long-term haemodialysis is due to the deposition of β2-microglobulin, the non-polymorphic light chain of class I major histocompatibility complex, that accumulates at bone joints into amyloid fibrils. Several lines of evidence show the relevance of the tryptophan residue at position 60 for the fibrillogenic transition of the protein. A comparative (15)N NMR relaxation...

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PMID: 24136818
DOI: 10.1002/mrc.4018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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