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Article

The Apparent Organ-Specificity of Amyloidogenic ApoA-I Variants Is Linked to Tissue-Specific Extracellular Matrix Components.

International journal of molecular sciences - 24 Dec 2022

Del Giudice Rita, Lindvall Mikaela, Nilsson Oktawia, Monti Daria Maria, Lagerstedt Jens O

Abstract excerpt

Apolipoprotein A-I (ApoA-I) amyloidosis is a rare protein misfolding disease where fibrils of the N-terminal domain of the protein accumulate in several organs, leading to their failure. Although ApoA-I amyloidosis is systemic, the different amyloidogenic variants show a preferential tissue accumulation that appears to correlate with the location of the mutation in the protein sequence and with the local...

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Identifiers

PMID: 36613763
DOI: 10.3390/ijms24010318
PMCID: PMC9820410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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