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Article

Effects of mutation on the amyloidogenic propensity of apolipoprotein C-II(60-70) peptide.

Physical chemistry chemical physics : PCCP - 28 Nov 2010

Todorova Nevena, Hung Andrew, Maaser Simon M, Griffin Michael D W, Karas John, Howlett Geoffrey J, Yarovsky Irene

Abstract excerpt

Using experimental and computational methods we identified the effects of mutation on the structure and dynamics of the amyloidogenic peptide apoC-II(60-70), in monomeric and oligomeric states. Methionine (Met60) substitutions to hydrophilic Gln, hydrophobic Val, and methionine sulfoxide residues were investigated and the results compared with observations of fibril formation by the wild-type, Met60Gln, Met60Val,...

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Amyloid
Apolipoprotein C-II
Models, Theoretical
Molecular Dynamics Simulation
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Secondary

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PMID: 20938536
DOI: 10.1039/c0cp00299b

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