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Article

The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils.

Journal of lipid research - 1 Mar 2012

Petrlova Jitka, Duong Trang, Cochran Megan C, Axelsson Annika, Mörgelin Matthias, Roberts Linda M, Lagerstedt Jens O

Abstract excerpt

A number of amyloidogenic variants of apoA-I have been discovered but most have not been analyzed. Previously, we showed that the G26R mutation of apoA-I leads to increased β-strand structure, increased N-terminal protease susceptibility, and increased fibril formation after several days of incubation. In vivo, this and other variants mutated in the N-terminal domain (residues 26 to ∼90) lead to renal and hepatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22184756
DOI: 10.1194/jlr.M020883
PMCID: PMC3276462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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