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Article

Understanding the role of apolipoproteinA-I in atherosclerosis. Post-translational modifications synergize dysfunction?

Biochimica et biophysica acta. General subjects - 1 Jan 2021

Ludovico Ivo Díaz, Gisonno Romina A, Gonzalez Marina C, Garda Horacio A, Ramella Nahuel A, Tricerri M Alejandra

Abstract excerpt

BACKGROUND: The identification of dysfunctional human apolipoprotein A-I (apoA-I) in atherosclerotic plaques suggests that protein structure and function may be hampered under a chronic pro inflammatory scenario. Moreover, the fact that natural mutants of this protein elicit severe cardiovascular diseases (CVD) strongly indicates that the native folding could shift due to the mutation, yielding a structure more...

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Source

Identifiers

PMID: 32946930
DOI: 10.1016/j.bbagen.2020.129732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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