Article

Understanding the role of apolipoproteinA-I in atherosclerosis. Post-translational modifications synergize dysfunction?

2020-06-10

Abstract excerpt

<h4>Background</h4> The identification of dysfunctional human apolipoprotein A-I (apoA-I) in atherosclerotic plaques suggests that protein structure and function may be hampered under a chronic pro inflammatory scenario. Moreover, the fact that natural mutants of this protein elicit severe cardiovascular diseases (CVD) strongly indicates that the native folding could shift due to the mutation, yielding a structur...

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Literature Corpus work: b9a28711-a1ef-5035-9a5a-73dfc1997911
DOI: 10.1101/2020.06.09.142844

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