Article
Fibrillar conformation of an apolipoprotein A-I variant involved in amyloidosis and atherosclerosis.
Biochimica et biophysica acta. General subjects - 1 Apr 2020
Gisonno Romina A, Prieto Eduardo D, Gorgojo Juan P, Curto Lucrecia M, Rodriguez M Eugenia, Rosú Silvana A, Gaddi Gisela M, Finarelli Gabriela S, Cortez M Fernanda, Schinella Guillermo R, Tricerri M Alejandra, Ramella Nahuel A
Abstract excerpt
BACKGROUND: Different protein conformations may be involved in the development of clinical manifestations associated with human amyloidosis. Although a fibrillar conformation is usually the signature of damage in the tissues of patients, it is not clear whether this species is per se the cause or the consequence of the disease. Hereditary amyloidosis due to variants of apolipoprotein A-I (apoA-I) with a...
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