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A tumor necrosis factor-α responsive cryptic promoter drives overexpression of the human endogenous retrovirus <i>ERVK-7</i>

2025-03-13

Abstract excerpt

Endogenous retroviruses (ERVs) shape human genome functionality and influence disease pathogenesis, including cancer. ERVK-7 , a significant ERV, acts as an immune modulator and prognostic marker in lung adenocarcinoma (LUAD). Although ERVK-7 overexpression has been linked to the amplification of the 1q22 locus in approximately 10% of LUAD cases, it predominantly arises from alternative regulatory mechanisms. Ou...

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Literature Corpus work
6e76cd58-6aba-55de-bb50-ebb0dbbc347c
DOI
10.1101/2025.03.09.642286
Open publication

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