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Endogenous retrovirus activation: potential for immunology and clinical applications

25 Jan 2024

Abstract excerpt

Endogenous retroviruses (ERVs), the remnants of ancient retrovirus infections, constitute approximately 8% of the human genome and play important roles in human evolution, development, and diseases. Multiple drugs, such as DNA methyltransferase inhibitors and lysine-specific histone demethylase 1 inhibitors, reactivate ERVs, induce viral mimicry and trigger innate immune responses to enhance tumor immunogenicity....

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PMID: 38495812
DOI: 10.1093/nsr/nwae034

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