Article

Regulatory Features and Functional Specialization of Human Endogenous Retroviral LTRs: A Genome-Wide Annotation and Analysis via HERVarium

2026-02-18

Abstract excerpt

Human endogenous retroviruses (HERVs), remnants of ancient retroviral infections, account for over 8% of the human genome and remain an underexplored source of cis-regulatory elements and protein-coding remnants. Here we present HERVarium, an integrated and interactive database that provides access to systematic annotations of the protein-domain architecture of internal HERV regions and the regulatory landscape of...

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Literature Corpus work: 53114a0d-dbdd-55f8-b0b5-ce692313d1e2
DOI: 10.64898/2026.02.17.706328

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