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Article

Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers

14 Mar 2023

Abstract excerpt

Small-cell lung cancer (SCLC) is an aggressive cancer characterized by immunosuppressive features leading to poor responses to current immunotherapies. Activation of transposable elements (TE) can trigger an innate immune response, which can synergize with immunotherapeutic protocols in patients. However, TE activity in relation to immune gene response is not fully known in human SCLC. Here, we compared TE...

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PMID: 36918931
DOI: 10.1186/s13100-023-00290-w

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